1. Main points

  • There were 3,346 drug poisoning deaths registered in England and Wales in 2014, the highest since comparable records began in 1993

  • Of these, 2,248 (or 67%) were drug misuse deaths involving illegal drugs

  • The mortality rate from drug misuse was the highest ever recorded at 39.9 deaths per million population

  • Males were over 2.5 times more likely to die from drug misuse than females (58.0 and 21.9 deaths per million population for males and females respectively)

  • Deaths involving heroin and/or morphine increased by almost two-thirds between 2012 and 2014, from 579 to 952 deaths

  • Deaths involving cocaine increased sharply to 247 in 2014 – up from 169 deaths in 2013

  • People aged 40 to 49 had the highest mortality rate from drug misuse (88.4 deaths per million population); followed by people aged 30 to 39 (87.9 deaths per million)

  • In England there was a 17% rise in the drug misuse mortality rate in 2014, to 39.7 per million population, while in Wales the rate fell by 16% to 39.0 deaths per million, the lowest since 2006

  • Within England, the North East had the highest mortality rate from drug misuse in 2014 for the second year running (69.3 deaths per million population), while London had the lowest (25.4 deaths per million)

  • All figures presented in this bulletin are based on deaths registered in a particular calendar year. Out of the 3,346 drug-related deaths registered in 2014, half (1,682) occurred in years before 2014

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2. Important information

This bulletin presents the latest figures from the Office for National Statistics (ONS) on deaths related to drug poisoning (involving both legal and illegal drugs) and drug misuse (involving illegal drugs) in England and Wales. Figures from 1993 onwards are available to download, and are discussed in the commentary to provide further context to the latest data.

Drug use and drug dependence are known causes of premature mortality, with drug poisoning accounting for 1 in 7 deaths among people in their 20s and 30s in 2014 (see Background note 6). Drug-related deaths occur in a variety of circumstances, each with different social and policy implications. Consequently, there is considerable political, media and public interest in these figures.

This bulletin covers accidents and suicides involving drug poisonings, as well as deaths from drug abuse and drug dependence. It doesn’t include other adverse effects of drugs (for example, anaphylactic shock). Drug poisoning deaths involve a broad spectrum of substances, including legal and illegal drugs, prescription-type drugs (either prescribed to the individual or obtained by other means) and over-the-counter medications. Some of these deaths may also be from complications of drug abuse, such as deep vein thrombosis or septicaemia from intravenous drug use, rather than an acute drug overdose.

The definition of a drug misuse death is (a) deaths where the underlying cause is drug abuse or drug dependence and (b) deaths where the underlying cause is drug poisoning and where any of the substances controlled under the Misuse of Drugs Act 1971 are involved. This definition has been used across the UK. More details can be found in Background note 5.

The figures presented here are for deaths registered each year, rather than deaths occurring each year. Almost all drug-related deaths are certified by a coroner. Due to the length of time it takes a coroner to complete an inquest, half of drug-related deaths registered in 2014 will have actually occurred prior to 2014. See the "Impact of registration delays on drug-related deaths" section below for more information. Nevertheless, general trends in drug-related deaths are broadly equivalent, regardless of whether the data is analysed by year of occurrence or year of registration. Extra information is provided in the commentary where differences in the trends do exist.

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3. Deaths from all drug poisonings

There were 3,346 drug poisoning deaths (involving both legal and illegal drugs) registered in 2014. As in previous years, the majority (just over two-thirds) of these deaths were males (2,246 male deaths and 1,100 female deaths).

In 2014, the mortality rate for all drug-related deaths increased significantly for both males and females to 80.7 and 38.8 deaths per million population respectively. This increase is likely to be related to the availability and consumption of heroin/morphine (see the "heroin and morphine" section).

Figure 3 shows that the mortality rate from all drug poisoning is significantly higher in males than in females. The Crime Survey for England and Wales showed that men are more likely to take illicit drugs than women (Home Office, 2015a). This partly explains the higher mortality rate from drug poisoning in males. However, this cannot be the only explanation, as more than 30% of drug poisoning deaths are not related to drug misuse.

There have been significant rises in the male mortality rates for all drug-related poisonings over the last 2 years. The mortality rate reached 80.7 deaths per million population in 2014, the highest since 2001. This reverses the declining trend that had been seen between 2009 and 2012. Before this, the male mortality rate for all drug-related poisonings rose steeply from 1993 and peaked in 1999. Since then, mortality rates have been lower but there have been large fluctuations over the years, especially over the 11-year period from 1999 to 2009.

Female mortality rates have steadily increased each year since 2009. They showed a particularly marked 19% increase in 2014, reaching an all time high of 38.8 deaths per million population in 2014. This follows on from relatively stable rates between 1993 and 2004 and then a declining trend, reaching the lowest level in 2007 (26.6 deaths per million population).

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6. Opiates

Opiate drugs can be prescribed to treat moderate to severe pain, but repeated use can lead to dependence and tolerance (meaning the user needs to take more of the drug to achieve the same effect). These drugs also have psychoactive effects and many opiates are taken illicitly due to this a high abuse potential.

Over half (53%) of all deaths related to drug poisoning in 2014 involved an opiate drug (excluding opiates which are contained in paracetamol compounds such as co-codamol). This proportion has been relatively stable since 2007.

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7. Heroin and morphine

Deaths involving heroin and/or morphine increased from 579 in 2012 to 952 in 2014 (an increase of almost two-thirds) and they remain the most commonly mentioned opiates in drug related deaths.

Figure 4 shows that before the recent rise, the mortality rate for deaths involving heroin and/or morphine declined between 2008 and 2012, with a particularly sharp drop between 2009 and 2011. The recent reversal means the mortality rate in 2014 was the highest since 2001 and now exceeds the previous peak in 2008 seen before the "heroin drought" (see following paragraph). The number of deaths from heroin/morphine reported here is likely to be an underestimate, as some coroners simply record "opiate overdose" on the death certificate and do not specify which opiate drug was involved. Many of these deaths will actually involve heroin/morphine.

Increases in the number of deaths involving heroin/morphine were seen across all ages between 2013 and 2014, apart from people aged 70 and over, with the biggest rises seen in those aged 50 to 69 (see Reference table 7). However, a different pattern of heroin/morphine-related mortality was seen for males and females. In males, the mortality rate for deaths involving heroin and/or morphine decreased in 2012, then rose sharply in 2013 and increased again in 2014 (by 19%). In contrast, female mortality rates rose by 18% in 2012, remained stable in 2013, and then increased by 46% in 2014. Some of this difference between the sexes can be explained by the fact that a greater proportion of female deaths involving heroin/morphine are suicides (rather than accidental overdoses), which are less likely to be affected by changes in the purity of heroin.

Evidence suggests that in 2010/11 there was a "heroin drought" in the UK, with reduced availability of heroin persisting in some areas in 2011/12 and 2012/13 (Serious Organised Crime Agency (SOCA), 2011, 2012, 2013, 2014). The heroin drought affected the purity of user-level or "street" heroin, which fell from 46% in September 2009 (SOCA, 2011) to 17% in mid-2012 (National Crime Agency, 2015), then increased again in the last 2 years to an average of 29% in 2013 and 36% in 2014. This is consistent with the UN report suggesting that global opium poppy cultivation (the source of heroin) reached its highest level in 2014 since the 1930s (United Nations, 2015). Prices of heroin have also changed over this period – the purity-adjusted price of heroin per gram in the United Kingdom has fallen from £74.32 in 2011 to £49.55 in 2013 (United Kingdom Focal Point on Drugs, 2014). This means people can now take stronger heroin for the same price.

Public Health England (2014) report that the number of people starting treatment for heroin and/or crack addiction (including those returning to treatment) increased slightly between 2012/13 and 2013/14. Frontline drug workers who responded to the Street Drug Trends Survey in 2014 suggested the slight upturn in people coming into services may be related to the higher purity heroin in circulation (Drugscope, 2015).

Evidence suggests that overdoses are associated with higher drug purity (Bazazi et al, 2015) so the increase in user-level purity, and the changes in price, may partly explain the increase in heroin related deaths in 2013 and 2014. However, we would expect this to affect males and females in a similar way, so the different pattern of mortality seen for males and females suggests the increase in purity is not the only factor.

Heroin/morphine is particularly dangerous when taken in combination with other central nervous system depressant drugs such as methadone, tramadol, benzodiazepines and alcohol, as these drugs interact with heroin and can lead to marked respiratory depression resulting in a high risk of overdose. Over time, there has been a gradual increase in the number of deaths mentioning heroin/morphine in combination with other substances in England and Wales. Although this cannot fully explain the recent sharp increases in deaths involving heroin/morphine, it is possible that changes in the specific drugs taken with heroin/morphine in recent years may be having an impact.

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8. Other opiates, including tramadol and methadone

Reference table 6a shows that deaths involving the majority of other opiates, including painkillers such as tramadol, codeine, oxycodone and fentanyl and unspecified opiates have also increased in recent years.

A notable trend to emerge in the past few years is the steady increase in the number of deaths mentioning tramadol (a synthetic opioid analgesic). This rise continued in 2014 where the number of deaths involving tramadol increased by 9% to a new peak of 240 deaths. However, the number of tramadol prescriptions remained stable in 2014 (HSCIC, 2014 and 2015). This suggests that the increase in deaths may be due to people misusing this substance. In June 2014, tramadol was controlled under the Misuse of Drugs Act 1971 as a class C substance (Home Office, 2014a), but we will need to wait for the 2015 death registrations to be reported to us to find out whether this has had an impact on deaths.

In contrast, deaths involving methadone have shown the opposite trend in 2014, when there were 394 deaths, down 8% from 2013. Methadone is an opiate substance used to treat heroin addiction, which is sometimes abused.

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9. Cocaine

There were 247 deaths involving cocaine in 2014. Deaths involving cocaine increased steadily in the 1990s and 2000s, peaking in 2008, before declining slightly between 2008 and 2011. However, mortality rates have increased 3 years in a row, and have now reached an all time high of 4.4 deaths per million population.

The Crime Survey for England and Wales suggests that cocaine is the second most commonly used drug (after cannabis) with 2.4% of adults aged 16 to 59 using powder cocaine in 2013/14. This was slightly higher than in 2012/13 (1.9%), although this remains lower than the peak of 3.0% in 2008/09 (Home Office, 2015a). The National Crime Agency (2015) suggest there has been a gradual increase in user-level cocaine purity over the last 2 years, and there were marked regional variations in the purity of crack cocaine. These 2 factors are likely to be contributing to the increase in deaths involving cocaine.

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10. Amphetamines, including ecstasy

The number of deaths involving amphetamines increased from 120 in 2013 to 151 in 2014. This is a mortality rate of 2.6 deaths per million population, which is the highest mortality rate since records began in 1993. In addition to amphetamine itself, the amphetamines group includes substances such as methylenedioxymethamphetamine (MDMA, also known as ecstasy), methylamphetamine, paramethoxyamphetamine (PMA) and Para-methoxymethamphetamine (PMMA).

The number of deaths involving ecstasy has varied across the years. The highest number of deaths was seen in 2005 when there were 58 deaths, this then declined to a low of 8 deaths in 2010. Since then the number of deaths has gradually increased to 50 deaths in 2014. The Home Office reported a rise in ecstasy use by adults aged 15 to 59 between 2012/13 and 2013/2014, but this has since stabilised (Home Office, 2015a).

Reports have expressed concerns about the availability of "super strength" ecstasy, with one recent formulation having a reported MDMA content around 2 to 2.5 times the standard MDMA dose per pill (Drugscope, 2015). The Street Drug Trends Survey (Drugscope, 2015) reports that ecstasy purity levels have increased significantly and have now reached 1990s levels. In addition, ecstasy is sometimes taken in combination with the more potent PMA. This may partially explain the increased number of deaths involving ecstasy.

The number of death certificates mentioning PMA or PMMA dropped slightly in 2014 from 29 in 2013 to 24 in 2014. It is too soon to say if this is the end of the increasing trend seen since 2011, and the figure is still far higher than the single death seen in 2011. It has been suggested that people may be ingesting PMA or PMMA in the belief that they are taking ecstasy tablets (Frank, 2013). However, there is not enough information recorded on coroner’s death certificates to confirm if this was the case for the deaths registered in 2014.

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12. Benzodiazepines

There were 372 drug-related deaths involving benzodiazepines in 2014. The mortality rate was 6.6 deaths per million population, an 8% increase from 2013 and the highest mortality rate since records began in 1993.

Diazepam was the most common type of benzodiazepine mentioned on deaths certificates in 2014, involved in 258 deaths, the highest number on record. Although diazepam can be prescribed it is also widely abused. The Street Trends Drug Survey suggests that the content of these illegal benzodiazepines varies and there is a trend for taking new benzodiazepine analogues such as etizolam (Drugscope, 2015).

The role of diazepam and other benzodiazepines in drug-related deaths is unclear, as more than 9 out of 10 deaths involving benzodiazepines also mentioned another, often more potent, drug such as heroin or methadone.

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13. Zopiclone and zolpidem

The number of deaths involving zopiclone or zolpidem has steadily increased since 1993 to 100 deaths in 2014, an increase of 16% since 2013. These drugs are prescribed to treat insomnia in the short-term, and prescriptions have increased slightly (2% between 2013 and 2014 – HSCIC, 2015), but this does not explain the growing number of deaths involving these substances. These drugs have the potential to be misused and in June 2014, zopiclone was controlled under the Misuse of Drugs Act 1971 as a class C substance (Home Office, 2014a), but it is too soon to say whether this has had any impact on the number of deaths. As with benzodiazepines, 8 out of 10 deaths involving Zopiclone or Zolpidem also involve another drug.

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14. Antidepressants

There were 517 deaths involving antidepressants in 2014, the highest number since 1999. The majority of this increase is in people aged between 40 and 69.

Deaths involving tricyclic antidepressants (TCAs) showed an increase in 2014, with 253 deaths registered in 2014. The majority of the TCA deaths involved amitriptyline where there was a 13% rise to 195 deaths, continuing the upward trend since 2010. Although TCAs are still involved in more deaths than other types of antidepressants, the number of deaths from TCA poisoning is now much lower than its peak of 497 deaths in 1998.

Deaths involving Selective Serotonin Re-uptake Inhibitors (SSRIs) have been steadily increasing over recent years, reaching a peak of 159 deaths in 2014, 1 death higher than the previous peak in 2012. The majority of SSRI deaths involve the drug citalopram. The number of these deaths had been increasing gradually over time, but in 2013 there was a decrease of 19% to 82 deaths. This increased again slightly in 2014 to 86 deaths. Studies show that SSRIs are less toxic in overdose than TCAs (Hawton et al, 2010), but SSRIs are prescribed more frequently. In the last 5 years prescriptions for SSRIs have increased more rapidly than prescriptions for TCAs (Health and Social Care Information Centre – HSCIC, 2010 and 2014), which may explain the gradual long-term rise in deaths involving SSRIs.

Deaths involving other types of antidepressants have continued the upward trend, increasing by 26% and reaching a peak in 2014 at 155 deaths. Reference table 6a shows that the majority of these deaths involved venlafaxine or mirtazapine. The number of deaths involving mirtazapine increased to 90 deaths in 2014 from 73 in 2013, the highest number on record. Deaths involving venlafaxine also increased to the highest number on record (59 deaths in 2014). The National Institute for Health and Clinical Excellence guidelines (NICE, 2009) suggest that these drugs should not be used as a first-line treatment for depression, and should only be prescribed to people who have not responded to SSRIs. Venlafaxine in particular is associated with a greater risk of death from overdose. Prescriptions for venlafaxine and mirtazapine have increased in recent years, but still only accounted for only 16% of all antidepressant prescriptions in 2014 and yet they were responsible for 29% of deaths where antidepressants were mentioned (HSCIC, 2014 and 2015).

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15. Paracetamol and other analgesics

There were 200 deaths involving paracetamol and its compounds in 2014. Deaths involving paracetamol not from a compound decreased by 20% in 2014 to 127, following a small increase in 2013. Overall, deaths involving paracetamol not from a compound have been fairly stable in the last few years. However, deaths involving co-codamol (paracetamol and codeine) increased by 21% in 2014 to a new high of 63 deaths.

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16. Barbiturates

In 2014 the number of deaths involving barbiturates increased by 56%, from 32 up to 50 deaths – an all time high. Although there has been some fluctuation, the data appears to suggest that since 2007 there has been an increasing trend, peaking in 2014.

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17. Antipsychotics

There were 126 deaths related to antipsychotics in 2014 (an 18% increase). This continues the gradually increasing trend that has been seen since around 2000. The number of deaths involving antipsychotics reached an all time high in 2014 and is now more than twice the level recorded in 1994. In 2014, the antipsychotic quetiapine was involved in half these cases (52 deaths). The number of prescriptions for antipsychotic drugs increased in 2014, but not as much as the number of deaths (HSCIC, 2014 and 2015). The reason for this difference is unclear.

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20. Comparisons with other countries

Figures on drug-related deaths in Scotland are available from National Records of Scotland. These show that there were 613 deaths related to drug misuse registered in Scotland in 2014, 16% higher than in 2013. Additional data on Scottish drug-related deaths is available from the Information Services Division of NHS Scotland.

Figures for Northern Ireland are available from the Northern Ireland Statistics and Research Agency. The latest figures show that there were 115 drug-related deaths registered in Northern Ireland in 2013, up 5% compared with 2012.

Statistics for Europe are available from the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). The latest figures show that the UK had the seventh highest drug-related mortality rate in Europe (EMCDDA, 2015).

Figures for other countries may not be comparable with those presented here for England and Wales, due to differences in data collection methods and in the death registration system.

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23. New method for calculating confidence intervals around mortality rates

The deaths data in this release are not subject to sampling variation, as they were not drawn from a sample. Nevertheless, they may be affected by random variation, particularly where the number of deaths is small. To help assess the variability in the rates, they have been presented alongside 95% confidence intervals.

This bulletin uses a new method for calculating the confidence intervals around the death rates, and figures have been revised back to 1993. Previously, the confidence intervals were calculated using a normal approximation method, on the assumption that the underlying deaths data on which the rates are based on are normally distributed. However, in some instances, for example in young people, the number of drug-related deaths is relatively small (fewer than 100), and may be assumed to follow a Poisson probability distribution. In such cases, it is more appropriate to use the confidence limit factors from a Poisson probability distribution table to calculate the confidence intervals, instead of a normal approximation method. The method used to calculate confidence intervals for death rates based on fewer than 100 deaths was proposed by Dobson et al, (1991), and was described in APHO (2008) The previous normal approximation method is still used to calculate 95% confidence intervals where there are 100 or more deaths in a year.

A benefit of the new method is that because the Poisson probability distribution is asymmetric and has a lower bound of 0, the lower confidence interval will never fall below 0 (unlike the normal approximation).

These changes do not affect the death rate – only the confidence interval around the rate. The impact is generally small and affects groups where there are less than 100 deaths, for example, Wales and English regions; females; younger and older age groups and specific substances.

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24. Changes to the coding of underlying cause of death

We code cause of death using the World Health Organization's (WHO) International Classification of Diseases, Tenth Revision (ICD-10). Where possible, deaths are automatically coded using specialist software, with the remaining deaths being manually coded. ICD-10 was introduced in England and Wales in January 2001. Since then various amendments to the ICD-10 have been authorised by WHO and we have updated cause coding software to incorporate these changes. Between 2001 and 2010, we used software version 2001.2; between 2011 and 2013 version 2010 was used and on 1 January 2014, we changed the software to a package called IRIS (version 2013). IRIS software version 2013 incorporates all official updates to ICD-10 approved by WHO, which were timetabled for implementation before 2014.

To understand the impact of these changes on mortality statistics, we carried out bridge coding studies in which a sample of deaths that had previously been coded using the old software were then independently recoded using the new version of ICD-10 (Office for National Statistics, 2011 and 2014a).

The move to v2010 in 2011 had a big impact on the assignment of underlying cause of death for drug-related deaths, causing a large reduction in deaths with an underlying cause of a mental and behavioural disorder and a corresponding increase in deaths with an accidental underlying cause. It did not, however, affect the total number of drug-related deaths. More information about the impact of this coding change on drug-related deaths statistics can be found in the 2012 statistical bulletin (Office for National Statistics, 2012).

The move to IRIS (version 2013) software in 2014 was expected to cause a small decrease in the number of drug-related deaths, due to a change in the coding of deaths involving helium. Almost all of these deaths are suicides and until 2014 they would have been assigned an underlying cause of X64 or Y14 (poisoning by other and unspecified drugs, medicaments and biological substances). From 2014, deaths involving helium are assigned an underlying cause of X67 or Y17 (poisoning by other gases and vapours), and are no longer included in the range of codes used to select drug-related deaths (see Background note 4). Consequently, the total number of drug-related deaths are approximately 2% lower in 2014 than they would have been had the coding change not been implemented.

In addition, analysis of the bridge coded data suggested a small increase in deaths assigned an accidental poisoning underlying cause and a corresponding decrease in deaths assigned to mental and behavioural disorder due to drug use. The selection of 1 of these 2 causes is dependent on the precise wording on the death certificate and due to the small number of drug-related deaths in the bridge coded data (around 200) it is possible these changes are simply random noise in the data.

This means figures for 2011 onwards by underlying cause will not be directly comparable with figures for 2001 to 2010.

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25. Policy context

The current Government drug strategy, "Reducing demand, restricting supply, building recovery: supporting people to live a drug-free life" (Home Office, 2010), highlights the prevention of drug-related deaths as one of the key outcomes that recovery-oriented services should be focused on. The Government has also placed an increased emphasis on drug prevention alongside drug treatment across all substances and drug using cohorts. In April 2013, responsibility for public health – including drug and alcohol prevention and treatment – transferred from the NHS to local authorities.

Patterns of drug use change over time. For instance, in recent years people have been taking new psychoactive substances (NPS), sometimes referred to as "legal highs". In response to this, last year the Government commissioned an expert panel to look at ways to tackle NPS. Following the recommendations of the review, in May 2015, the Government introduced the Psychoactive Substances Bill in the House of Lords. Under the Bill it will be an offence to supply any substance intended for human consumption that is capable of producing a psychoactive effect (Home Office, 2015b).

In February 2013, the Welsh Government published the Substance Misuse Delivery Plan 2013–2015 (Welsh Government, 2013), which included the specific target of "reducing the number of substance misuse related deaths and non-fatal overdoses and alcohol poisonings in Wales". To support this, guidance for undertaking fatal and non-fatal drug poisoning reviews has been developed and the Welsh Government are now working with partners to implement the guidance.

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26. Uses made of this data

The figures contained in this bulletin are used by a range of public bodies, such as Public Health England (PHE), the Department of Health (DH), the Home Office and the Welsh Government to evaluate the effectiveness of various drug strategies. For example, the 2014 expert panel review of new psychoactive substances and the Home Offices own review of the evidence made use of our drug-related deaths data (Expert Panel, 2014 and Home Office, 2014b).

In April 2013, the key functions of the National Treatment Agency for Substance Misuse were transferred into PHE, and they have linked our data on drug-related deaths with data from the English National Drug Treatment Monitoring System (NDTMS). This study suggested that the English public treatment system for opioid use disorder prevented an average of 880 deaths each year from opioid-related poisoning (White et al, 2015).

The Welsh Government (2011) and Public Health Wales have linked our drug-related deaths data to information on the distribution and coverage of the National Take-Home Naloxone (THN) programme. This will be used to evaluate whether the THN program is having an impact on the number of drug-related deaths in Wales and also to identify areas requiring further focus.

The European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) combines data for England and Wales from our drug poisoning database with data from Scotland and Northern Ireland to publish UK figures. This allows comparisons to be made with other European countries. The 2015 European drug report shows that the drug-related mortality rate in the UK was the seventh highest in Europe (EMCDDA, 2015). However, caution should be applied when making international comparisons, because of differences in definitions and the quality of reporting.

Our drug poisoning data are also used by academic researchers. For example, analysis of this data by the Centre for Suicide Research at the University of Oxford revealed that there was a major reduction in deaths involving co-proxamol following its withdrawal in 2005, with no evidence of an increase in deaths involving other analgesics, apart from oxycodone (Hawton et al, 2012). Updated data on deaths involving co-proxamol and other analgesics are shown in Reference table 6a.

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27 .References

  1. The Advisory Council on the Misuse of Drugs (2000) Reducing drug related deaths, Home Office: London

  2. APHO – Association of Public Health Observatories, (2008) "Technical Briefing 3 – Commonly used public health statistics and their confidence intervals", accessed on 19 August 2015

  3. Bazazi A.R. et al (2015) "High prevalence of non-fatal overdose among people who inject drugs in Malaysia: correlates of overdose and implications for overdose prevention from a cross-sectional study", International Journal of Drug Policy, 26, 675–681, accessed on 26 August 2015

  4. Christophersen O, Rooney C and Kelly S (1998) "Drug related deaths: methods and trends (1.9 Mb Pdf)", Population Trends 93, 29–37, accessed on 19 August 2015

  5. Department of Health (2001) "The Government Response to the Advisory Council on the Misuse of Drugs Report into Drug Related Deaths", accessed on 19 August 2015

  6. Dobson, A, Kuulasmaa K, Eberle E and Scherer J (1991) "Confidence intervals for weighted sums of poisson parameters" , accessed on 19 August 2015

  7. Drugscope (2014) ‘Business as usual? A status report on new psychoactive substances (NPS) and club drugs in the UK’

  8. Drugscope (2015) ‘Down a stony road: The 2014 DrugScope Street Drug Survey’

  9. EMCDDA – European Monitoring Centre for Drugs and Drug Addiction (2015) "European Drug Report 2015: Trends and developments", accessed on 19 August 2015

  10. Expert Panel (2014) "New Psychoactive Substances Review", accessed on 19 August 2015

  11. Frank (2013) "What is PMA?", accessed on 19 August 2015

  12. Hawton K, Bergen H, Simkin S, Wells C, Kapur N and Gunnell D (2012) "Six-Year Follow-Up of Impact of Co-proxamol Withdrawal in England and Wales on Prescribing and Deaths: Time-Series Study", PLOS Medicine, accessed on 19 August 2015

  13. Home Office (2010) "Drug Strategy 2010 – Reducing demand, restricting supply, building recovery: supporting people to live a drug-free life" , accessed on 19 August 2015

  14. Home office (2014a) "Circular 008/2014: changes to the Misuse of Drugs Act 1971", accessed on 19 August 2015

  15. Home Office (2014b) "New psychoactive substances in England: a review of the evidence", accessed on 19 August 2015

  16. Home office (2015a) "Drug misuse: Findings from the 2014/15 Crime Survey for England and Wales", accessed on 19 August 2015

  17. Home Office (2015b) "Creation of a blanket ban on new psychoactive substances in the UK", accessed on 19 August 2015

  18. HSCIC – Health and Social Care Information Centre (2010) "Prescription Cost Analysis: England 2009", accessed on 19 August 2015

  19. HSCIC – Health and Social Care Information Centre (2014) "Prescription Cost Analysis: England 2013", accessed on 19 August 2015

  20. HSCIC – Health and Social Care Information Centre (2015) "Prescription Cost Analysis: England 2014", accessed on 19 August 2015

  21. "The Misuse of Drugs Act (1971)", The Stationery Office Ltd, accessed on 19 August 2015

  22. National Crime Agency (2015), personal communication

  23. NICE – National Institute for Health and Clinical Excellence (2009) "Depression in adults: The treatment and management of depression in adults", accessed on 19 August 2015

  24. Office for National Statistics (2002) "Report: Deaths related to drug poisoning: results for England and Wales, 1993 to 2000", Health Statistics Quarterly 13, 76–82, accessed on 19 August 2015

  25. Office for National Statistics (2011) "Results of the ICD-10 v2010 bridge coding study, England and Wales, 2009", accessed on 19 August 2015

  26. Office for National Statistics (2012) "Deaths Related to Drug Poisoning in England and Wales, 2011", accessed on 19 August 2015

  27. Office for National Statistics (2014a) "Impact of the Implementation of IRIS Software for ICD-10 Cause of Death Coding on Mortality Statistics, England and Wales", accessed on 19 August 2015

  28. Office for National Statistics (2014b) "The impact of using the 2013 European Standard Population to calculate mortality and cancer incidence rates", accessed on 19 August 2015

  29. Public health England (2013) "Drug treatment in England 2012-13", accessed on 19 August 2015

  30. Public Health England (2014) "Drug treatment in England 2013-14", accessed on 19 August 2015

  31. SOCA (2011) "Serious Organised Crime Agency Annual Report and Accounts 2010/11", accessed on 19 August 2015

  32. SOCA (2012) "Serious Organised Crime Agency Annual Report and Accounts 2011/12", accessed on 19 August 2015

  33. SOCA (2013) "Serious Organised Crime Agency Annual Report and Accounts 2012/13", accessed on 19 August 2015

  34. SOCA (2014) "Serious Organised Crime Agency Annual Report and Accounts 2013/14", accessed on 19 August 2015

  35. United Kingdom Focal Point on Drugs (2014) "United Kingdom Drug Situation"

  36. United Nations (2015) "World Annual Drug Report", accessed on 19 August 2015

  37. Welsh Government (2011) "Evaluation of the Take Home Naloxone Demonstration Project", accessed on 19 August 2015

  38. Welsh Government (2013) "Substance Misuse Delivery Plan 2013 – 2015", accessed on 19 August 2015

  39. White et al (2015) "Fatal opioid poisoning: a counterfactual model to estimate the preventive effect of treatment for opioid use disorder in England", Addiction 110(8), 1321-9, accessed on 19 August 2015

  40. World Health Organisation – WHO (2010) "International Statistical Classification of Diseases and Related Health Problems, volumes 1, 2 and 3 (Tenth Revision)", WHO: Geneva, accessed on 19 August 2015

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28 .Background notes

  1. Quality information

    Further information about the quality of drug-related deaths data can be found in the Quality and Methodology Information (QMI) paper (494.7 Kb Pdf).

  2. Mortality metadata

    Information about the underlying mortality data, including details on how the data is collected and coded are available in the mortality metadata (2.46 Mb Pdf).

  3. Drug poisoning database

    The figures presented in this bulletin have been produced using a special database of deaths related to drug poisoning. This has been developed to facilitate research into these deaths and to aid the identification of specific substances involved. The database is extracted from the national mortality database for England and Wales. Deaths are included if the underlying cause of death is regarded as drug-related, according to the National Statistics definition. More information on this definition and issues relating to the interpretation of drug-related deaths data can be found in Christophersen et al (1998). (103.5 Kb Pdf). Almost all deaths on the drug poisoning database had a coroner’s inquest. For each death the database includes the following information:

    • the ICD codes for underlying cause of death and other causes mentioned on the death certificate
    • every mention of a substance recorded by the coroner in the cause of death section or elsewhere on the coroner's certificate after inquest (up to seven substances)
    • an indicator to show if alcohol is mentioned – this includes a wide variety of scenarios ranging from evidence of alcohol consumption around the time of death (for example, an empty vodka bottle found at the scene or alcohol found after toxicology tests) to long-term alcohol abuse and cirrhosis of the liver
    • other information recorded at death registration such as age, sex, marital status, occupation and place of usual residence
  4. Definition of a drug-related death

  5. Definition of a death related to drug misuse

    In 2000, the Advisory Council on the Misuse of Drugs published a report called "Reducing Drug Related Deaths" (The Advisory Council on the Misuse of Drugs, 2000). In response to this report’s recommendations on improving the present system for collecting data on drug-related deaths, a technical working group was set up. This group, consisting of experts across government, the devolved administrations, coroners, toxicologists and drugs agencies, proposed a headline indicator for drug misuse deaths as part of the government’s action plan (Department of Health, 2001), to reduce the number of these deaths. This indicator also takes into account the information needs of the European Monitoring Centre for Drugs and Drug Addiction. The baseline year for monitoring deaths related to drug misuse was set as 1999. The definition of the headline indicator using ICD-10 is shown below. The definition using ICD-9 was published in a previous annual report (Office for National Statistics (723.4 Kb Pdf), 2002).

    Cause of death categories included in the headline indicator of drug misuse deaths (the relevant ICD-10 codes are given in brackets):

    a) Deaths where the underlying cause of death has been coded to one of the following categories of mental and behavioural disorders due to psychoactive substance use (excluding alcohol, tobacco and volatile solvents):

    • opioids (F11)
    • cannabinoids (F12)
    • sedatives or hypnotics (F13)
    • cocaine (F14)
    • other stimulants, including caffeine (F15)
    • halucinogens (F16)
    • multiple drug use and use of other psychoactive substances (F19)

    b) Deaths where the underlying cause of death has been coded to one of the following categories and where a drug controlled under the Misuse of Drugs Act 1971, was mentioned on the death certificate:

    • Accidental poisoning by drugs, medicaments and biological substances (X40–X44)
    • Intentional self-poisoning by drugs, medicaments and biological substances (X60–X64)
    • Poisoning by drugs, medicaments and biological substances, undetermined intent (Y10–Y14)
    • Assault by drugs, medicaments and biological substances (X85)
    • Mental and behavioural disorders due to use of volatile solvents (F18)


    i. Specific rules were adopted for dealing with compound analgesics which contain relatively small quantities of drugs listed under the Misuse of Drugs Act, the major ones being dextropropoxyphene, dihydrocodeine and codeine. Where these drugs are mentioned on a death record, they have been excluded from the drug misuse indicator if they are part of a compound analgesic (such as co-proxamol, co-dydramol or co-codamol) or cold remedy. Dextropropoxyphene has been excluded on all occasions, whether or not paracetamol or a compound analgesic was mentioned. This is because dextropropoxyphene is rarely, if ever, available other than as part of a paracetamol compound. However, codeine or dihydrocodeine mentioned without paracetamol or ibuprofen were included in the indicator. This is because they are routinely available and known to be abused in this form. This approach is the same as that taken by National Records of Scotland (NRS). Drugs controlled under the Misuse of Drugs Act 1971 include class A, B and C drugs.

  6. Deaths among people in their 20s and 30s

    Around 1 in 7 deaths among people in their 20s and 30s were drug-related. This figure has been calculated from the number of deaths from all drug poisonings of people aged 20 to 39, (1,275 deaths) and the number of deaths from all causes in this age group (8,725 deaths) for England and Wales in 2014. The number of deaths from all causes, by sex and age is available on the our website.

  7. Heroin and morphine

    Heroin (diamorphine) breaks down in the body into morphine, so either heroin and/or morphine may be detected at post mortem and recorded on the death certificate. Therefore a combined figure for deaths where heroin or morphine was mentioned on the death certificate is included in Table 1.

  8. Cocaine

    The figure for cocaine in Table 1 includes deaths where cocaine was taken in the form of crack cocaine. It is not possible to separately identify crack cocaine from other forms of cocaine at post mortem. Other evidence to distinguish the form of cocaine taken is rarely provided on death certificates.

  9. GHB and GBL

    The figure for GHB (gamma-hydroxybutyrate) in Reference table 6a includes deaths where GBL (gamma-butyrolactone) was taken. It is not possible to separately identify GBL and GHB at post mortem as GBL is rapidly converted to GHB when ingested into the human body.

  10. List of drugs included as new psychoactive substances

    There is no national statistics definition of new psychoactive substances. The following substances have been included in this group in this bulletin:

    • 1-(benzofuran-5-yl)-N-methylpropan-2-amine
    • 1-(Benzofuran-5-yl)-propan-2-amine
    • 1-(Benzofuran-6-yl)-propan-2-amine
    • 2-(1H-Indol-5-yl)-1-methylethylamine
    • 25B-NBOMe
    • 25C-NBOMe
    • 2-diphenylmethylpyrrolidine
    • 4,4’-DMAR
    • 4-Fluoroephedrine
    • 4-Fluoromethcathinone
    • 4-Methoxymethcathinone
    • 4-Methylamphetamine
    • 4-Methylethcathinone
    • 5-EAPB
    • 5F-AKB-48
    • AH-7921
    • Alpha-methyltryptamine
    • APB
    • BZP
    • Cathinone
    • Desoxypipradrol
    • Diphenidine
    • Etizolam
    • Flubromazepam
    • Fluoromethamphetamine
    • Fluoromethcathinone
    • GHB
    • Khat
    • MDDA
    • Mephedrone
    • Methiopropamine
    • Methoxetamine
    • Methoxphenidine
    • Methylenedioxypyrovalerone
    • Methylethcathinone
    • Methylone
    • N-Methyl-3-phenyl-norbornan-2-amine
    • Pyrazolam
    • Synthetic cannabinoid
    • TFMPP

    It is likely that this list will be revised in future as new substances emerge, and we welcome comments on the grouping.

  11. Calculation of mortality rates

    Mortality rates are presented as deaths per one million population. The mortality rates in Figure 6 are age-specific rates; and those in Figures 3, 4 and 7 are directly age-standardised to the 2013 European standard population. Age-standardised rates are used to allow comparison between populations which may contain different proportions of people of different ages, including comparisons between males and females and over time. Eurostat, the statistical institute of the European Union, has decided to update the European Standard Population, which is used in the calculation of age-standardised rates. More information can be found on the our website.

  12. Confidence intervals

    Excel workbooks containing the data used to produce the figures and tables in this bulletin are available to download from the our website. These tables contain both the mortality rate and the upper and lower confidence limits. These limits form a confidence interval, which is a measure of the statistical precision of an estimate and shows the range of uncertainty around the estimated figure. Calculations based on small numbers of events are often subject to random fluctuations. As a general rule, if the confidence interval around one figure overlaps with the interval around another, we cannot say with certainty that there is more than a chance difference between the two figures. Within this statistical bulletin, a difference which is described as "significant", means "statistically significant", assessed by examining the confidence intervals.

  13. Revisions

    The ONS revisions policy is available on our website.

  14. Calculation of registration delays

    Figure 10 presents data on the length of time taken to register a death (also known as the registration delay) for drug-related deaths. This is calculated as the difference between the date each death occurred and the date it was registered, measured in days. Data where the exact date of death was unknown or where either the date of death or date of registration was clearly recorded incorrectly (that is, the death appeared to have been registered before it occurred) were excluded from this analysis. Approximately 0.2% of the data were excluded for these reasons. Analysis showed that the data was positively skewed, and contains some deaths with very long registration delays (for example, more than eight years). Therefore the average registration delay has been presented using the median value, as this is not influenced by extreme values. The median is defined as the value that is halfway through the ordered data set, below and above which there lies an equal number of data values.

  15. Special extracts of data

    Special extracts and tabulations of drug poisoning deaths data are available to order (subject to legal frameworks, disclosure control and agreement of costs, where appropriate). Enquiries should be made to:

    Mortality Analysis Team, Life Events and Population Sources Division
    Office for National Statistics
    Government Buildings
    Cardiff Road
    NP10 8XG

    Tel: +44 (0)1633 455341
    Email: mortality@ons.gsi.gov.uk

    Our charging policy is available on the our website.

  16. Feedback

    We would welcome feedback on the content, format and relevance of this release. Please send feedback to the postal or email address above.

  17. Pre-release access

    A list of the names of those given pre-publication access to the statistics and written commentary is available in this pre-release access list for deaths related to drug poisoning in England and Wales in 2014. The rules and principles which govern pre-release access are featured within the Pre-release Access to Official Statistics Order 2008.

  18. National Statistics

    The UK Statistics Authority has designated these statistics as National Statistics, in accordance with the Statistics and Registration Service Act 2007 and signifying compliance with the Code of Practice for Official Statistics.

    Designation can be broadly interpreted to mean that the statistics:

    • meet identified user needs
    • are well explained and readily accessible
    • are produced according to sound methods
    • are managed impartially and objectively in the public interest

    Once statistics have been designated as National Statistics it is a statutory requirement that the Code of Practice shall continue to be observed

  19. Social Media

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  20. Terms and conditions

    You may use or re-use this information (not including logos) free of charge in any format or medium, under the terms of the Open Government Licence. To view this licence, visit the National Archives website, write to: The Information Policy Team, The National Archives, Kew, London TW9 4DU, or email: psi@nationalarchives.gsi.gov.uk.

  21. Details of the policy governing the release of new data are available by visiting www.statisticsauthority.gov.uk/assessment/code-of-practice/index.html or from the Media Relations Office email: media.relations@ons.gsi.gov.uk

    These National Statistics are produced to high professional standards and released according to the arrangements approved by the UK Statistics Authority.

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Contact details for this Statistical bulletin

Vanessa Fearn
Telephone: +44 (0)1633 455341