"Figure 5: Rates of deaths involving methadone significantly increased in 2021","" "Age-standardised mortality rates for deaths by all opiates, heroin or morphine, and methadone, England and Wales, registered between 1993 and 2021","" "","" "Notes","1. Age-standardised mortality rates per million people, standardised to the 2013 European Standard Population. 2. Cause of death was defined using the International Classification of Diseases, Ninth Revision (ICD-9) for the years 1993 to 2000 and Tenth Revision (ICD-10) from 2001 onwards. More details can be found in the [Quality and Methodology Information](https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/methodologies/deathsrelatedtodrugpoisoninginenglandandwalesqmi). 3. Figures are for deaths registered, rather than deaths occurring in each calendar year. 4. Figures for England and Wales include deaths of non-residents." "Unit","Age-standardised rate per million people" "","" "Year of death registration","Any opiate","Heroin or morphine","Methadone" "1993","8.4","2.7","3.5" "1994","11.5","4.8","4.5" "1995","13.5","5.8","5.3" "1996","16.1","7.7","5.6" "1997","18.5","7.8","7.7" "1998","20.6","10.8","7.0" "1999","23.9","13.4","6.0" "2000","24.2","15.1","4.8" "2001","27.1","17.4","4.4" "2002","23.6","15.4","3.5" "2003","19.6","12.4","3.5" "2004","21.1","13.4","3.9" "2005","23.5","14.9","3.9" "2006","22.2","12.6","4.3" "2007","25.0","14.6","5.7" "2008","28.0","15.8","6.6" "2009","28.3","15.5","7.1" "2010","27.2","14.0","6.2" "2011","25.6","10.5","8.5" "2012","23.0","10.3","7.3" "2013","28.3","13.6","7.6" "2014","31.8","16.9","7.0" "2015","35.3","21.3","7.7" "2016","35.9","21.3","7.3" "2017","34.9","20.5","6.5" "2018","38.7","23.4","7.4" "2019","37.9","23.3","7.2" "2020","39.7","23.4","9.1" "2021","38.7","21.1","11.7"